Herbal Guduchi Information: Herbal Guduchi or Tinospora Cordifolia is a large, climbing shrub. Guduchi is an important part of the Ayurvedic category of Rasayanas, or rejuvenative tonics. GuduchiGuduchi Enhances the functioning of protective cells, macrophages, and improves body's resistance to infections. Guduchi is useful as a diuretic, helps removes urinary stones and reduce blood urea. Guduchi inhibits growth of bacteria and enhances the buildup of immune resistance. Guduchi possesses antibacterial, anti-inflammatory, anti-rheumatic, and anti-allergic properties. helps increase the effectiveness of protective white blood cells and builds up the body's own defense mechanism (immune system).

Herbal Guduchi Usage: Guduchi is a Cholagogue, detoxicant, alterative, immune tonic, anti-inflammatory, diuretic, anthelmintic, nervine.

Guduchi acts as a diuretic and found to be effective against Renal obstruction like calculi and other urinary disorders.

Guduchi acts as a memory booster, develops inteligence, promotes mental clarity. It is described as one of the Medhya Rasayana (mental rejuvenative) in the Charak Samhita (The oldest and most potent book of Ayurvedic Medicine).

Guduchi is regarded as a liver protector. Liver damage, viral hepatitis or poisoning from alcohol, chemicals or recreational and medicinal drugs. Useful in repairing fibrosis and regenerating liver tissue. 2 Applied in all conditions of aggravated ranjakapitta and pitta in the blood.

Guduchi is useful in joints gout (vatarakta), arthritis (amavata) and other inflammatory joint conditions. 2 It acts by clearing pitta toxins and uric acid via the urinary system that have accumulated in raktavahasrotas. It also removes ama toxins from the system without destabilising any of the other dosha.

Guduchi is considered helpful in eye disorders as a tissue builder and promotes mental clarity.

GIT Guduchi heals a bowel affected with constipation, intestinal bleeding, haemorrhoids or dysentery. Useful at redressing intestinal floral imbalance with candida-like symptoms (krimi, grahani) such as bloating, flatulence and malabsorption. Its bitter yet heating qualities are used to stimulate raktadhatvagni and strengthen digestion in pitta types.

The stem of Guduchi is used in general debility, dyspepsia and urinary diseases.

Guduchi is a Metabolic. It regulates blood sugar levels via its direct effect on rakta and medas-dhatu thus benefiting diabetes and hypoglycaemia. Guduchi is very calming to vata and the nervous system via its unctuous nature soothing nervous irritation.

Guduchi is anti-pyretic and act as a tonic after fever, also has action against alternative fever like Malaria.

Guduchi is a Reproductive Its ability to clear heat is applied when sexual dysfunction is caused by a hyper-heat condition. It is often used in formulas for male sexual dysfunction caused by pitta imbalance as its sweet post-digestive effect nourishes shukradhatu.

Herbal Guduchi Dosage: Take 1 or 2 capsules twice daily with meals. Allow several weeks for benefits.

Herbal Guduchi Side Effects:
None

Herbal Guduchi Drug Interactions:
None

Herbal Guduchi Contraindications:
None

Herbal Guduchi Clinical Studies:

1. Mechanism of macrophage activation by (1,4)/alpha/D/glucan isolated from Tinospora cordifolia. (Research Institute, Miami Children's Hospital, Miami, FL 33155, USA.)
   
   The signaling mechanism of the novel (1,4)/alpha/D/glucan (RR1) isolated from
   the medicinal plant Tinospora cordifolia was investigated in macrophages to
   evaluate its immunostimulating properties. When RAW264.7 macrophages were incubated with RR1 at 4 degrees C, the novel glucan inhibited the phagocytosis of unopsonized zymosan A bioparticles in a dose/dependent manner. RR1 also inhibited the binding and internalization of opsonized zymosan A bioparticles, although at a lower level than laminarin. Incubation of macrophages with anti/CD11b mAb followed by RR1 failed to show any inhibitory effect on RR1/induced TNF/alpha synthesis confirming that complement receptor 3 (CR3) is not involved in the opsonic binding and internalization of RR1 in macrophages unlike zymosan A. The anti/CD11b mAb has significant inhibitory effect on the zymosan A/induced tumor necrosis factor (TNF)/alpha synthesis. RR1 induced TNF/alpha synthesis in macrophages in a dose/dependent manner which can be completely inhibited by the NF/kappaB inhibitor caffeic acid phenethyl ester (CAPE) or curcumin. RR1 activated NF/kappaB in a time/ and dose/dependent manner and this modulation of nuclear NF/kappaB activity is associated with the degradation of I/kappaB alpha thus facilitating the translocation of NF/kappaB into the nucleus. RR1/induced NF/kappaB activity peaks at 8 h of RR1 stimulation while I/kappaB alpha degradation occurred within 1 h of stimulation. RR1/induced NF/kappaB activation occurred through TLR6 signaling as evidenced by the synthesis of IL/8 in TLR6/transfected HEK293 cells. These results show that the novel (1,4)/alpha/D/glucan from Tinospora cordifolia activates the immu ne system
   through the activation of macrophages that occurs through TLR6 signaling,
   NF/kappaB translocation and cytokine production.
   
2. Immunostimulatory effect of Tinospora cordifolia Miers leaf extract in Oreochromis mossambicus.(Indian J Exp Biol. 2006 Sep;44(9):726/32.)
   Immunostimulatory effect of leaf extract of T. cordifolia on (i) specific immunity (antibody response), (ii) non/specific immunity (neutrophil activity) and (iii) disease resistance against Aeromonas hydrophila was investigated in O. mossambicus. Ethanol and petroleum ether extracts of the leaves were used. Both ethanol and petroleum ether extracts administered at doses of 0.8, 8 or 80 mg/kg body weight, prolonged the peak primary antibody titres upto one to three weeks. Ethanol extract at the dose of 8 mg/kg and petroleum ether extract at the doses of 0.8 or 8 mg/kg enhanced the secondary antibody response. All the doses of ethanol extract significantly enhanced neutrophil activity. Fish injected with petroleum ether or ethanol extract at a dose of 8 mg/kg were protected against experimental infection with virulent A. hydrophila. The results indicates the potential of T. cordifolia leaf extracts for use as an immunoprophylactic to prevent diseases in finfish aquaculture.